Messi, 30, looks set to finish his career at Barca after extending his contract until 2021 on Wednesday.
The Argentina international has developed into one of the greatest players of all-time and Henry – who played for the LaLiga giants from 2007-10 – knows Messi is irreplaceable.
The Frenchman compared Messi’s place to that of Leonardo Da Vinci’s famous painting Mona Lisa, which is on display at the Louvre in Paris.
Asked in a Gatorade promotional video if Messi would ever be replaced at Barcelona, Henry said: “Do you think the Mona Lisa will ever be replaced at the Louvre?”
Henry and Messi played three seasons together at Barca, winning two LaLiga titles and a Champions League among numerous other trophies.
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